This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Function:
TOM1 may be involved in intracellular trafficking. In conjunction with Tollip it plays an important role in recruiting clathrin onto endosomes and may modulate endosomal functions.
Subunit:
Interacts with ZFYVE16; interaction is required to target it to endosomes.
Subcellular Location:
Cytoplasm. Membrane; Peripheral membrane protein
Tissue Specificity:
Widely expressed. Highly expressed in skeletal muscle, heart, placenta and liver
Similarity:
Belongs to the TOM1 family.
Contains 1 GAT domain.
Contains 1 VHS domain.
SWISS:
O60784
Gene ID:
10043
Database links:
Entrez Gene: 10043 Human
Entrez Gene: 608746 Dog
Entrez Gene: 21968 Mouse
Entrez Gene: 361370 Rat
Entrez Gene: 717499 Rhesus monkey
Omim: 604700 Human
SwissProt: O60784 Human
SwissProt: O88746 Mouse
SwissProt: Q5XI21 Rat
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