SBEM is a 90 amino acid secreted membrane protein that may play a role as marker for the diagnosis of metastatic breast cancer. SBEM contains three tandem copies of a neutral octapeptide core repeat, and its N- and SLCterminal regions are charged and fairly polar. These features are similar to many sialomucins, although the SBEM protein lacks a transmembrane domain and is shorter than most other known epithelial mucins. Expressed in mammary, salivary glands, prostate and also in lung, SBEM is mainly expressed in cancer cell lines of breast origin. SBEM is also highly expressed in lymph node-positive compared with node-negative tumors and in all lymph node containing metastatic cells. The SBEM gene is conserved in chimpanzee, cow, mouse, rat, chicken, zebrafish, C.elegans and M.grisea, and maps to human chromosome 12q13.2.
Function:
May play a role as marker for the diagnosis of metastatic breast cancer.
Subcellular Location:
O-glycosylated.
Tissue Specificity:
Expressed in mammary, salivary glands and prostate. Also detected in lung. Mainly expressed in cancer cell lines of breast origin. Highly expressed in lymph node-positive compared with node-negative tumors. Detected in all lymph node containing metastatic cells.
Post-translational modifications:
O-glycosylated.
SWISS:
Q96DR8
Gene ID:
11843
Database links:
Entrez Gene: 118430 Human
Omim: 610857 Human
SwissProt: Q96DR8 Human
Unigene: 348419 Human
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