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C9orf126; FLJ11758; FLJ36664; MGC120525; MGC120526; MGC120528; NET40; Protein SCAI; SCAI; SCAI_HUMAN; Suppressor of cancer cell invasion; Suppressor of cancer cell invasion protein.
Cat:
SL17260R
Species Reactivity：
(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,)
Immunogen：
KLH conjugated synthetic peptide derived from human SCAI:101-200/606
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
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Product PDFs
Datasheet:


This gene encodes a regulator of cell migration. The encoded protein appears to function in the RhoA (ras homolog gene family, member A)-Dia1 (diaphanous homolog 1) signal transduction pathway. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

Function:
Tumor suppressor which functions to suppress MKL1-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1.

Subunit:
Interacts with DIAPH1 (By similarity). Forms a nuclear ternary complex with MKL1 and SRF.

Subcellular Location:
Membrane. Nucleus. Cytoplasm. Nuclear localization is required for inhibition of MKL1.

Similarity:
Belongs to the SCAI family.

SWISS:
Q8N9R8

Gene ID:
286205

Database links:

Entrez Gene: 286205 Human

Entrez Gene: 64271 Mouse

Entrez Gene: 690538 Rat

SwissProt: Q8N9R8 Human

SwissProt: Q8C8N2 Mouse

Unigene: 59504 Human

Unigene: 204836 Mouse

Unigene: 206053 Rat



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