Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane regions, and a short SLCterminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]).[supplied by OMIM, Feb 2011]
Function:
Probably involved in membrane protein trafficking.
Subcellular Location:
Membrane.
Similarity:
Belongs to the SCAMP family.
SWISS:
Q969E2
Gene ID:
113178
Database links:
Entrez Gene: 113178 Human
Entrez Gene: 56214 Mouse
Entrez Gene: 65170 Rat
Omim: 613764 Human
SwissProt: Q969E2 Human
SwissProt: Q9JKV5 Mouse
SwissProt: Q9ET20 Rat
Unigene: 144196 Human
Unigene: 273170 Mouse
Unigene: 7309 Rat
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