Acetyl LDL receptor;
Endothelial cells scavenger receptor;
SCARF1;
Scavenger receptor class F member 1;
Scavenger receptor expressed by endothelial cells 1;
Scavenger receptor expressed by endothelial cells;
SREC;
SREC-I;
SREC_HUMAN.
Cat:
SL17272R
Species Reactivity：
(predicted: Human,Mouse,Rat,Dog,Pig,Horse,)
Immunogen：
KLH conjugated synthetic peptide derived from human SCARF1:21-120/830<Extracellular>
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Function: Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein. Plays a role in the regulation of neurite-like outgrowth.
Subunit: Heterophilic interaction with SREC2 via its extracellular domain. The heterophilic interaction is suppressed by the presence of ligand such as Ac-LDL. Interacts with AVIL (By similarity).
Specific References (1) | SL17272R has been referenced in 1 publications.
[IF=4.799] Ranran Zhang. et al. The Role of SRESLCⅠ in Innate Immunity to Aspergillus fumigatus Keratitis. Invest Ophth Vis Sci. 2021 Jul;62(9):12-12 IF ; Mouse.
