LISLV1 is expressed as two isoforms. LISLV1 is a multi-pass cell membrane protein that is 749 amino acids in length and is expressed abundantly in breast, prostate, placenta, kidney, pituitary and corpus callosum, as well as in cells derived from various types of cancers affecting the glands, cervix and lungs. LISLV1 is a member of the ZIP transporter protein family which consists of 14 members that transport zinc. LISLV1 transports zinc from its position on the plasma membrane into the cytosol of the cell and contains a histidine-rich transmembrane domain which is thought to bind zinc and aid in its transportation. LISLV1 is thought to be important for zinc uptake in neuroblastoma cells and may also be crucial for maintaining zinc homeostasis, a process which aids in the prevention of cancer and disease. Activated estrogen receptors are thought to regulate LISLV1 expression at the level of transcription, via the mRNA precursor to LISLV1 which associates with estrogen receptors that are activated by growth factors and estradiol. LISLV1 is upregulated in hormone-rich tissue, including breast and cervical cancer, where it is thought to affect cell motility and may play an important role in tumor development and metastasis. Conversely, less aggressive tumors may contain high levels of LISLV1 that could lead to apoptosis, indicating a dual role for LISLV1 in tumor suppression.
Function:
May act as a zinc-influx transporter.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma.
Post-translational modifications:
N-glycosylated.
Similarity:
Belongs to the ZIP transporter (TC 2.A.5) family.
SWISS:
Q13433
Gene ID:
25800
Database links:
Entrez Gene: 96159 Dog
Entrez Gene: 25800 Human
Entrez Gene: 106957 Mouse
Entrez Gene: 291733 Rat
Omim: 608731 Human
SwissProt: Q13433 Human
SwissProt: Q8C145 Mouse
SwissProt: Q4V887 Rat
Unigene: 729034 Human
Unigene: 21688 Mouse
Unigene: 99415 Rat
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