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Rabbit Anti-PIG54/SCC112 antibody
The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Function:
Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.
Subcellular Location:
Nucleus. Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase.
Tissue Specificity:
Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue. Isoform 2 is expressed in kidney.
Similarity:
Belongs to the PDS5 family.
Contains 1 HEAT repeat.
SWISS:
Q29RF7
Gene ID:
23244
Database links:
Entrez Gene: 23244 Human
Omim: 61640 Human
SwissProt: Q29RF7 Human
Unigene: 331431 Human
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