Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Subcellular Location:
Nucleus.
Tissue Specificity:
Strongly expressed in heart, muscle and pancreas. Weakly expressed in brain, placenta, lung, liver and kidney.
Similarity:
Belongs to the SCM family.
Contains 2 MBT repeats.
Contains 1 SAM (sterile alpha motif) domain.
SWISS:
Q96GD3
Gene ID:
22955
Database links:
Entrez Gene: 22955 Human
Entrez Gene: 29871 Mouse
SwissProt: Q96GD3 Human
SwissProt: Q8K214 Mouse
Unigene: 571874 Human
Unigene: 427014 Mouse
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