This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]
Function:
Possesses negatively supercoiled DNA relaxing activity.
Tissue Specificity:
Isoform 1 is found in testis, heart and skeletal muscle. A 4 kb transcript which probably represents isoform 2 is found in thymus, kidney and pancreas.
Similarity:
Belongs to the prokaryotic type I/III topoisomerase family.
Contains 1 Toprim domain.
SWISS:
O95985
Gene ID:
8940
Database links:
Entrez Gene: 8940 Human
Entrez Gene: 21976 Mouse
Omim: 603582 Human
SwissProt: O95985 Human
SwissProt: Q9Z321 Mouse
Unigene: 431281 Human
Unigene: 326089 Mouse
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