TOX high mobility group box family member 4 (TOX4), also known as epidermal Langerhans cell protein 1 (LCP1), is a 621 amino acid protein that localizes to the nucleus. Mapping to chromosome 14q11.2, TOX4 contains one high mobility group (HMG) box DNA-binding domain, corresponding to amino acids 223 to 291 of human TOX4. The HMG box domain is a region of about 80 amino acids with unusual DNA binding preferences. HMG proteins bind DNA without sequence specificity. Furthermore, they bind to distorted or modified DNA and have the property to bend DNA. The presence of the HMG box DNA-binding domain suggests that TOX4 plays a role in transcriptional regulation.
Function:
Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. {ECO:0000269|PubMed:20516061}.
Subunit:
Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS. {ECO:0000269|PubMed:20516061}.
Subcellular Location:
Nucleus {ECO:0000305|PubMed:20516061}. Note=Associated with chromatin.
Similarity:
Contains 1 HMG box DNA-binding domain.
SWISS:
O94842
Gene ID:
9878
Database links:
Entrez Gene: 9878 Human
Entrez Gene: 515314 Cow
Entrez Gene: 475403 Dog
Entrez Gene: 268741 Mouse
Entrez Gene: 286990 Rat
SwissProt: Q0P5K4 Cow
SwissProt: O94842 Human
SwissProt: Q8BU11 Mouse
SwissProt: Q99PM1 Rat
Unigene: 555910 Human
Unigene: 246237 Mouse
Unigene: 22195 Rat
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