Rabbit Anti-hnRNP H antibody

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DKFZp686A15170; Heterogeneous nuclear ribonucleoprotein H; Heterogeneous nuclear ribonucleoprotein H1 (H); Heterogeneous nuclear ribonucleoprotein H1; HNRH1_HUMAN; hnRNP H; hnRNPH; hnRNPH1; HNRPH 1; HNRPH; HNRPH1 protein; N-terminally processed

Cat:

SL17333R

Species Reactivity：

(predicted: Human,Mouse,Rat,Zebrafish,Rhesus monkey, Gorilla, Opossum, Orangutan, Elephant)

Immunogen：

KLH conjugated synthetic peptide derived from human hnRNP H:151-250/449

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]

Function:
This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).

Subunit:
Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRNPH1. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with CUGBP1; the interaction is RNA-dependent. Interacts with MBNL1; the interaction in RNA-independent.

Subcellular Location:
Nucleus; nucleoplasm.

Tissue Specificity:
Expressed ubiquitously.

Similarity:
Contains 3 RRM (RNA recognition motif) domains.

SWISS:
P31943

Gene ID:
3187

Database links:

Entrez Gene: 3187 Human

Entrez Gene: 59013 Mouse

Entrez Gene: 140931 Rat

Omim: 601035 Human

SwissProt: P31943 Human

SwissProt: O35737 Mouse

SwissProt: Q8VHV7 Rat

Unigene: 604001 Human

Unigene: 21740 Mouse

Unigene: 23677 Rat

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