Rabbit Anti-hnRNP A/B antibody

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ABBP 1; ABBP-1; ABBP1; APOBEC1 binding protein 1; APOBEC1-binding protein 1; Apolipoprotein B mRNA editing enzyme catalytic polypeptide 1- protein 1; FLJ40338; Heterogeneous nuclear ribonucleoprotein A/B; hnRNP A/B; hnRNP type A/B protein; HNRNP

Cat:

SL17342R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human hnRNP A/B:1-100/332

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

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Other Information
Citations
Protein Attributes
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This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Function:
Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

Subcellular Location:
Nucleus. Cytoplasm. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Dimethylation at Arg-322 is probably asymmetric.

Similarity:
Contains 2 RRM (RNA recognition motif) domains.

SWISS:
Q99729

Gene ID:
3182

Database links:

Entrez Gene: 513410 Cow

Entrez Gene: 3182 Human

Entrez Gene: 15384 Mouse

Entrez Gene: 83498 Rat

Omim: 602688 Human

SwissProt: Q99729 Human

SwissProt: Q99020 Mouse

Unigene: 591731 Human

Unigene: 715055 Human

Unigene: 256875 Mouse

Unigene: 280842 Mouse

Unigene: 1427 Rat

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