This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus E1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by E1B-55kDa in adenovirus-infected cells. Two transcript variants encoding different isoforms have been found for this gene. Additional variants have also been found, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
Function:
Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro.
Subcellular Location:
Nucleus.
Post-translational modifications:
Methylated.
Similarity:
Contains 1 B30.2/SPRY domain.
Contains 1 SAP domain.
SWISS:
Q9BUJ2
Gene ID:
11100
Database links:
Entrez Gene: 11100 Human
Entrez Gene: 232989 Mouse
Entrez Gene: 361522 Rat
Omim: 605800 Human
SwissProt: Q9BUJ2 Human
SwissProt: Q8VDM6 Mouse
Unigene: 155218 Human
Unigene: 718642 Human
Unigene: 254223 Mouse
Unigene: 95170 Rat
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