This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008]
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the Abd-B homeobox family.
Contains 1 homeobox DNA-binding domain.
SWISS:
Q9NYD6
Gene ID:
3226
Database links:
Entrez Gene: 3226 Human
Entrez Gene: 209448 Mouse
Entrez Gene: 315338 Rat
Omim: 605560 Human
SwissProt: Q9NYD6 Human
SwissProt: P31257 Mouse
Unigene: 44276 Human
Unigene: 31665 Mouse
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