This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. [provided by RefSeq, Jul 2008]
Function:
Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.
Subunit:
Interacts with GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. Interacts with IFT57 and OPHN1. Isoform 1 encodes a coiled-coil structure that mediates homo- and heteromultimerization. {ECO:0000269|PubMed:10464340}.
Subcellular Location:
Cytoplasm. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction; synapse. Postsynaptic density of neuronal cells. Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum.
Similarity:
Belongs to the Homer family.
Contains 1 WH1 domain.
SWISS:
Q86YM7
Gene ID:
9456
Database links:
Entrez Gene: 9456 Human
Entrez Gene: 26556 Mouse
Entrez Gene: 29546 Rat
Omim: 604798 Human
SwissProt: Q86YM7 Human
SwissProt: Q9Z2Y3 Mouse
SwissProt: Q9Z214 Rat
Unigene: 591761 Human
Unigene: 37533 Mouse
Unigene: 37500 Rat
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