The Hox proteins play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. The mammalian HOX gene complex consists of 39 genes that are located on four linkage groups, which are dispersed over four chromosomes. A segment of the HoxB7 proximal promoter drives renal expression of reporter genes specifically in the ureteric bud and collecting ducts. Expression levels of HoxB7 are lower in lymph node metastasis-positive cancer tissues than negative cancer tissues. These results suggest that aberrant expression of HOX genes is related to the development of breast cancer and malignant behavior of cancer cells.
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the Antp homeobox family.
Contains 1 homeobox DNA-binding domain.
SWISS:
P09629
Gene ID:
3217
Database links:
Entrez Gene: 3217 Human
Entrez Gene: 15415 Mouse
Entrez Gene: 497985 Rat
Omim: 142962 Human
SwissProt: Q9TT89 Cow
SwissProt: P09629 Human
SwissProt: P09024 Mouse
SwissProt: P18864 Rat
Unigene: 436181 Human
Unigene: 390366 Mouse
Unigene: 113631 Rat
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