Heparan sulfate structures, which are responsible for executing multiple biological activities, are generated and regulated by heparan sulfate biosynthetic enzymes. HS3ST6 (Heparan sulfate glucosamine 3-O-sulfotransferase 6) is a 342 amino acid single-pass type II transmembrane protein that localizes to the golgi apparatus and belongs to the sulfotransferase 1 family. HS3ST6 transfers sulfate to the 3-OH position of the glucosamine residue of heparan sulfate to form 3-O-sulfated heparan sulfate. Due to observed susceptibility of HS3ST6-transfected CHO cells to HSSLV1 infection, it has been suggested that HS3ST6 produces a specific entry receptor for HSSLV1. The gene encoding HS3ST6 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome,
Function:
HS3ST6 is a single-pass type II membrane protein. It belongs to the sulfotransferase 1 family. It transfers a sulfuryl group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSSLV1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
Subcellular Location:
Golgi apparatus membrane; Single-pass type II membrane protein.
SWISS:
Q96QI5
Gene ID:
64711
Database links:
Entrez Gene: 64711 Human
Entrez Gene: 328779 Mouse
Entrez Gene: 684979 Rat
SwissProt: Q96QI5 Human
SwissProt: Q5GFD5 Mouse
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