Prokaryotic and eukaryotic cells respond to thermal and chemical stress by inducing a group of genes collectively designated heat shock genes. In eukaryotes, this gene expression is regulated primarily at the transcription level. Heat shock transcription factors 1 and 2 (HSF1 and HSF2), also designated HSTF1 and HSTF2, are involved in this regulation and are upregulated by estrogen at both the mRNA and protein level. HSF1 is normally found as a monomer, whose transcriptional activity is repressed by constitutive phosphorylation. Upon activation, HSF1 forms trimers, gains DNA binding activity and is translocated to the nucleus. HSBP1 (heat shock factor-binding protein 1), also known as HSF1BP or NPSLCA-13 (nasopharyngeal carcinoma-associated antigen 13), is a 76 amino acid nuclear protein that binds HSF1 and acts as a negative regulator of the heat shock response.
Function:
Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process.
Subunit:
Homohexamer. Associates with heptad repeats of HSF1 trimers and problaby also HSF1 monomers, and with HSP70. Association with HSF1 trimers and HSP70 coincides with attenuation of heat shock response and the conversion of HSF1 trimer to monomer.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the HSBP1 family.
SWISS:
O75506
Gene ID:
3281
Database links:
Entrez Gene: 3281 Human
Entrez Gene: 100038001 Pig
Entrez Gene: 286899 Rat
Entrez Gene: 393727 Zebrafish
Omim: 604553 Human
SwissProt: Q3ZC22 Cow
SwissProt: O75506 Human
SwissProt: A1XQV7 Pig
SwissProt: Q8K3X8 Rat
Unigene: 250899 Human
Unigene: 705549 Human
Unigene: 2578 Rat
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