Rabbit Anti-HSD17B12 antibody

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12,3-ketoacyl-CoA reductase,short chain; 17 beta HSD 12; 17 beta hydroxysteroid dehydrogenase 12; 17-@beta-HSD XII; 17-@beta-hydroxysteroid dehydrogenase XII; 17-beta-HSD 12; 17-beta-hydroxysteroid dehydrogenase 12; 17beta HSD type 12; 3 ketoacyl

Cat:

SL17401R

Species Reactivity：

(predicted: Human,Mouse,Rat,Recombinant Fragment Cynomolgus Monkey)

Immunogen：

KLH conjugated synthetic peptide derived from human HSD17B12:201-300/312

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011]

Function:
Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.

Subcellular Location:
Endoplasmic reticulum membrane.

Tissue Specificity:
Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets.

Similarity:
Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

SWISS:
Q53GQ0

Gene ID:
51144

Database links:

Entrez Gene: 51144 Human

Entrez Gene: 16813 Rat

Omim: 609574 Human

SwissProt: Q53GQ0 Human

SwissProt: Q6P7R8 Rat

Unigene: 132513 Human

Unigene: 203283 Rat

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