SID-1 and SID-2 belong to the systemic RNA interference defective-1 (SID1) family of transmembrane proteins. SID-1, originally identified in C. elegans, is an 827 amino acid protein. It localizes to the cell membrane and contains eleven transmembrane domains. This suggests that SID-1 possibly functions as a channel protein. The overexpression of SID-1 enhances double stranded RNA (dsRNA) uptake in pancreatic ductal adenocarcinoma cells. SID-2, also first identified in C. elegans, is an 832 amino acid protein with multiple transmembrane domains. At least two isoforms exist for SID-2 due to alternative splicing. Isoform 2 contains an additional 21 amino acids after residue 387 and has an alternate sequence that is 8 amino acids shorter for residues 814 to 832 of isoform 1.
Subcellular Location:
Membrane.
Similarity:
Belongs to the SID1 family.
SWISS:
Q9NXL6
Gene ID:
54847
Database links:
Entrez Gene: 54847 Human
Entrez Gene: 64007 Mouse
Entrez Gene: 288109 Rat
Omim: 606816 Human
SwissProt: Q9NXL6 Human
SwissProt: Q6AXF6 Mouse
SwissProt: Q6Q3F5 Rat
Unigene: 591291 Human
Unigene: 242144 Mouse
Unigene: 51246 Rat
|
|
