SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]
Function:
Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.
Subunit:
Interacts with IKBKE and TBK1 via its coiled coil region. Interaction with TBK1 is disrupted upon viral infection or TLR3 stimulation.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and leukocytes. Present in all cell lines tested (at protein level).
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the SIKE family.
SWISS:
Q9BRV8
Gene ID:
80143
Database links:
Entrez Gene: 80143 Human
Entrez Gene: 66641 Mouse
Entrez Gene: 362007 Rat
Omim: 611656 Human
SwissProt: Q9BRV8 Human
SwissProt: Q9CPR7 Mouse
SwissProt: Q5FWT9 Rat
Unigene: 709277 Human
Unigene: 208619 Mouse
Unigene: 9125 Rat
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