SIRPs are a family of transmembrane glycoproteins that were identified by their association with the Src homology 2 domain-containing protein-tyrosine phosphatase SHP-2 in response to insulin. The SIRP family negatively regulates the PI 3-kinase pathway, which may diminish EGFR-mediated motility and survival phenotypes that contribute to transformation of certain cell types. SIRP-alpha 1 is a transmembrane protein which acts as a substrate for activated receptor tyrosine kinases and, in its tyrosine phosphorylated form, binds to SH-PTP2 through SH2 interactions and acts as an SH-PTP2 substrate. SIRP-alpha 1 has been shown to have negative regulatory effects on cellular responses induced by growth factors, oncogenes and Insulin. SIRP-beta 1 shares extensive sequence homology with SIRP-alpha 1 in its extracellular portion but lacks the cytoplasmic portion. SIRP-beta 2 is a 342 amino acid multi-pass membrane protein that contains two Ig-like SLVtype (immunoglobulin-like) domains and exists as multiple alternatively spliced isoforms.
Subcellular Location:
Membrane.
Similarity:
Contains 2 Ig-like SLVtype (immunoglobulin-like) domains.
SWISS:
Q5JXA9
Gene ID:
284759
Database links:
Entrez Gene: 284759 Human
SwissProt: Q5JXA9 Human
Unigene: 721685 Human
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