This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNSLCbZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNSLCbZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, May 2009]
Function:
Transcriptional regulator that acts as repressor or activator. Binds, in-vitro, to NF-E2 binding sites. Play important roles in coordinating transcription activation and repression by MAFK.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the bZIP family. CNC subfamily.
Contains 1 BTB (POZ) domain.
Contains 1 bZIP domain.
SWISS:
O14867
Gene ID:
571
Database links:
Entrez Gene: 571 Human
Entrez Gene: 12013 Mouse
Entrez Gene: 304127 Rat
Omim: 602751 Human
SwissProt: O14867 Human
SwissProt: P97302 Mouse
Unigene: 154276 Human
Unigene: 721915 Human
Unigene: 26147 Mouse
Unigene: 29793 Rat
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