Sklud is a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Required for leg and eye development and macrochaete specification or differentiation. Negatively regulates sex comb development.
Function:
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for leg and eye development and macrochaete specification or differentiation. Negatively regulates sex comb development. Required for activated transcription of the MtnB and MtnD genes.
Subunit:
Component of the Cdk8 module of the Mediator complex, composed of CycC, Cdk8, kto and skd.
Subcellular Location:
Nuclear
Similarity:
Belongs to the Mediator complex subunit 13 family.
SWISS:
Q7KTX8
Gene ID:
43906
Database links:
Entrez Gene: 43906 Fruit fly (Drosophila melanogaster)
SwissProt: Q7KTX8 Fruit fly (Drosophila melanogaster)
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