Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]
Function:
Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
Subunit:
Homodimer or homotrimer. Interacts with VAPA.
Subcellular Location:
Cytoplasm. Golgi apparatus membrane. When bound to oxysterols, translocates to the periphery of Golgi membranes.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the OSBP family.
Contains 1 PH domain.
SWISS:
P22059
Gene ID:
5007
Database links:
Entrez Gene: 5007 Human
Entrez Gene: 76303 Mouse
Entrez Gene: 365410 Rat
Omim: 167040 Human
SwissProt: P22059 Human
SwissProt: Q3B7Z2 Mouse
Unigene: 597091 Human
Unigene: 291279 Mouse
Unigene: 107910 Rat
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