Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Function:
Regulator of osteoclastogenesis which plays an important bone-specific function in osteoclast differentiation.
Subcellular Location:
Secreted and Cell membrane.
Similarity:
Belongs to the leukocyte receptor complex/polymeric immunogobulin receptor (PIR/LRC) family.
Contains 2 Ig-like (immunoglobulin-like) domains.
SWISS:
Q8IYS5
Gene ID:
126014
Database links:
Entrez Gene: 126014 Human
Omim: 606862 Human
SwissProt: Q8IYS5 Human
Unigene: 347655 Human
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