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Rabbit Anti-Defensin alpha 5 antibody
Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.
Function:
Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.
Subcellular Location:
Secreted. Cytoplasmic vesicle, secretory vesicle. Peptides HD5(20-94), HD5(23-94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form.
Tissue Specificity:
Paneth cells of the small intestine (at protein level).
Post-translational modifications:
Glycosylated.
Similarity:
Belongs to the alpha-defensin family.
SWISS:
Q01523
Gene ID:
1670
Database links:
Entrez Gene: 1670 Human
Omim: 600472 Human
SwissProt: Q01523 Human
Unigene: 655233 Human
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