Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008]
Function:
Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Ubiquitously expressed. Present in osteoclasts (at protein level).
Similarity:
Contains 3 ANK repeats.
Contains 1 SH3 domain.
SWISS:
Q92882
Gene ID:
26578
Database links:
Entrez Gene: 427258 Chicken
Entrez Gene: 464532 Chimpanzee
Entrez Gene: 281961 Cow
Entrez Gene: 100063925 Horse
Entrez Gene: 26578 Human
Entrez Gene: 20409 Mouse
Entrez Gene: 397066 Pig
Entrez Gene: 259275 Rat
Entrez Gene: 703986 Rhesus monkey
Entrez Gene: 380103 Xenopus laevis
Entrez Gene: 549189 Xenopus tropicalis
Omim: 61036 Human
SwissProt: Q8MJ50 Cow
SwissProt: Q92882 Human
SwissProt: Q62422 Mouse
SwissProt: Q8MJ49 Pig
SwissProt: Q6P686 Rat
SwissProt: Q7ZYG4 Xenopus laevis
Unigene: 494192 Human
Unigene: 172222 Mouse
Unigene: 108470 Rat
Unigene: 7905 Xenopus laevis
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