Required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP.
Subcellular Location:
Membrane. Secreted > extracellular space. Detected in the gelatinous membrane overlying the inner ear macular epithelium.
Similarity:
Belongs to the otopetrin family.
SWISS:
Q7RTM1
Gene ID:
133060
Database links:
Entrez Gene: 133060 Human
Entrez Gene: 21906 Mouse
Omim: 607806 Human
SwissProt: Q7RTM1 Human
SwissProt: Q80VM9 Mouse
Unigene: 534544 Human
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