Otopetrins are multi-transmembrane domain proteins that share conserved gene and protein structure and are possibly involved in the formation of otoconia and otoliths. Located in the utricle and saccule of the inner ear, otoconia are complex calcium carbonate biominerals that are required for the normal sensation of gravity and linear acceleration. Vertigo and loss of balance may be attributed to degeneration of displacement of otoconia. The otopetrin family consists of three proteins, OTOP1, OTOP2 and OTOP3. These proteins have 12 putative transmembrane domains that are clustered into three otopetrin domains (OD-I, II and III). OTOP1 was the first described member of the Otopetrin family. Mutations of OTOP1 leads to absence of otoconia or otoliths, though inner ear development is normal. OTOP2 and OTOP3 share significant structural similarity with OTOP1 and may also play a role in the formation of mineralized structures.
Subcellular Location:
Membrane.
Similarity:
Belongs to the otopetrin family.
SWISS:
Q7RTS6
Gene ID:
92736
Database links:
Entrez Gene: 92736 Human
Entrez Gene: 237987 Mouse
Entrez Gene: 287820 Rat
Omim: 607827 Human
SwissProt: Q7RTS6 Human
SwissProt: Q80SX5 Mouse
Unigene: 352515 Human
Unigene: 44542 Mouse
Unigene: 218467 Rat
|
|
