Otospiralin is synthesized by nonsensory cells (fibrocytes) of the inner ear, and downregulation of otospiralin in guinea pigs leads to deafness (Lavigne-Rebillard et al., 2003 [PubMed 12687421]).[supplied by OMIM, Mar 2008]
Function:
May be essential for the survival of the neurosensory epithelium of the inner ear.
Subcellular Location:
Secreted.
Tissue Specificity:
Ear specific.
Similarity:
Belongs to the otospiralin family.
SWISS:
Q8NHW6
Gene ID:
150677
Database links:
Entrez Gene: 150677 Human
Entrez Gene: 260301 Mouse
Entrez Gene: 29244 Rat
Omim: 607877 Human
SwissProt: Q8NHW6 Human
SwissProt: Q8R448 Mouse
SwissProt: Q8K560 Rat
Unigene: 148586 Human
Unigene: 219545 Mouse
Unigene: 56698 Rat
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