Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. OTUD7A belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]
Function:
Has deubiquitinating activity that is directed towards 'Lys-48' or 'Lys-63'-linked polyubiquitin chains. Hydrolyzes both linear and branched forms of polyubiquitin.
Subcellular Location:
Cytoplasm. Nucleus.
Similarity:
Belongs to the peptidase C64 family.
Contains 1 A20-type zinc finger.
Contains 1 OTU domain.
SWISS:
Q8TE49
Gene ID:
161725
Database links:
Entrez Gene: 161725 Human
Omim: 612024 Human
SwissProt: Q8TE49 Human
Unigene: 355236 Human
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