This gene encodes a large, carbohydrate-rich, epithelial glycoprotein with numerous O-glycosylation sites located within threonine, serine, and proline-rich tandem repeats. The gene is similar to members of the mucin and the glycosyl hydrolase 18 gene families. Regulation of expression may be estrogen-dependent. Gene expression and protein secretion occur during late follicular development through early cleavage-stage embryonic development. The protein is secreted from non-ciliated oviductal epithelial cells and associates with ovulated oocytes, blastomeres, and spermatozoan acrosomal regions. [provided by RefSeq, Jul 2008]
Function:
Binds to oocyte zona pellucida in vivo. May play a role in the fertilization process and/or early embryonic development.
Subcellular Location:
Cytoplasmic vesicle; secretory vesicle. Secretory granules.
Tissue Specificity:
Oviduct.
Similarity:
Belongs to the glycosyl hydrolase 18 family.
SWISS:
Q12889
Gene ID:
5016
Database links:
Entrez Gene: 5016 Human
Entrez Gene: 12659 Mouse
Omim: 603578 Human
SwissProt: Q12889 Human
SwissProt: Q62010 Mouse
Unigene: 1154 Human
Unigene: 431947 Mouse
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