OXCT2 is a testis-specific succinyl-CoA:3-oxoacid CoA transferase (EC 2.8.3.5), which catalyzes the reversible transfer of CoA from succinyl-CoA to acetoacetate in the first step of ketone body utilization. See also OXCT1 (MIM 601424).[supplied by OMIM, Mar 2008]
Function:
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
Subcellular Location:
Mitochondrion.
Tissue Specificity:
Testis specific.
Similarity:
Belongs to the 3-oxoacid CoA-transferase family.
SWISS:
Q9BYC2
Gene ID:
12864
Database links:
Entrez Gene: 12864 Human
Omim: 610289 Human
SwissProt: Q9BYC2 Human
Unigene: 472491 Human
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