This gene encodes a beta-ketoacyl synthetase. The encoded enzyme is required for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]
Function:
May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.
Subcellular Location:
Mitochondrion.
Tissue Specificity:
Widely expressed. Higher expression in heart, skeletal muscle, liver and kidney which contain high levels of active mitochondria.
Similarity:
Belongs to the beta-ketoacyl-ACP synthases family.
SWISS:
Q9NWU1
Gene ID:
54995
Database links:
Entrez Gene: 513530 Cow
Entrez Gene: 54995 Human
Entrez Gene: 71147 Mouse
Entrez Gene: 289934 Rat
Omim: 610324 Human
SwissProt: Q0VCA7 Cow
SwissProt: Q9NWU1 Human
SwissProt: Q9D404 Mouse
Unigene: 55781 Human
Unigene: 197960 Mouse
Unigene: 24121 Rat
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