Rabbit Anti-WIPI2/Atg21 antibody

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ATG18B; Atg21; CGI 50; DKFZp434J154; DKFZp686P02188; FLJ12979; FLJ14217; FLJ42984; WD repeat domain phosphoinositide-interacting protein 2; WD repeat domain, phosphoinositide interacting 2; WD40 repeat protein interacting with phosphoinositides

Cat:

SL8767R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human WIPI2/Atg21:181-280/454

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008]

Function:
Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P.

Subunit:
Interacts with TECPR1.

Subcellular Location:
Preautophagosomal structure membrane. Enriched at preautophagosomal structure membranes in response to ptdIns3P.

Tissue Specificity:
Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors.

Similarity:
Belongs to the WD repeat SVP1 family.
Contains 3 WD repeats.

SWISS:
Q9Y4P8

Gene ID:
26100

Database links:

Entrez Gene: 26100 Human

Entrez Gene: 74781 Mouse

Entrez Gene: 288498 Rat

Omim: 609225 Human

SwissProt: Q9Y4P8 Human

SwissProt: Q80W47 Mouse

SwissProt: Q6AY57 Rat

Unigene: 122363 Human

Unigene: 29432 Mouse

Unigene: 163194 Rat

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