Rabbit Anti-SPACA1 antibody

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SACA1_HUMAN; SAMP32; SPACA1; Sperm acrosomal membrane-associated protein 32; Sperm acrosome membrane-associated protein 1.

Cat:

SL17614R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human SPACA1:51-150/294<Extracellular>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from infertile males. Furthermore, antibodies generated against the recombinant protein block in vitro fertilization. This protein localizes to the acrosomal membrane of spermatids and mature spermatozoa where it is thought to play a role in acrosomal morphogenesis and in sperm-egg binding and fusion, respectively. [provided by RefSeq, Jul 2008]

Function:
May be involved in sperm-egg fusion.

Subcellular Location:
Membrane.

Tissue Specificity:
Testis specific. At the equatorial segment and the inner acrosomal membrane of capacitated sperm.

SWISS:
Q9HBV2

Gene ID:
81833

Database links:

Entrez Gene: 81833 Human

Omim: 612739 Human

SwissProt: Q9HBV2 Human

Unigene: 161241 Human

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