Rabbit Anti-SPIRE1 antibody

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KIAA1135; MGC150621; MGC150622; Protein spire homolog 1; Spir 1; Spir-1; Spir1; SPIR1_HUMAN; SPIRE 1; Spire homolog 1; spire1.

Cat:

SL17677R

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human SPIRE1:651-756/756

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001 [PubMed 11747823]).[supplied by OMIM, Mar 2008]

Function:
Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in vesicle transport processes providing a novel link between actin organization and intracellular transport.

Subcellular Location:
Cytoplasm > cytoskeleton. Cytoplasm > perinuclear region. Punctate spots in perinuclear region and cytoplasm, co-localised with Rab11.

Similarity:
Belongs to the spire family.
Contains 1 KIND domain.
Contains 2 WH2 domains.

SWISS:
Q08AE8

Gene ID:
56907

Database links:

Entrez Gene: 56907 Human

Entrez Gene: 68166 Mouse

Omim: 609216 Human

SwissProt: Q08AE8 Human

SwissProt: Q52KF3 Mouse

Unigene: 515283 Human

Unigene: 208723 Mouse

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