This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence and is required for the early stages of spliceosome assembly. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Function:
SF1 contains 1 KH domain, 1 CCHC type zinc finger, a nuclear transport domain and glutamine and proline rich regions. It is necessary for the ATP dependent first step of spliceosome assembly and binds to the intron branch point sequence (BPS) 5' UACUAAC 3' of the pre mRNA. It may act as transcription repressor. There are 6 named isoforms produced by alternative splicing.
Subcellular Location:
Nuclear
Tissue Specificity:
Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart.
Post-translational modifications:
Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly. Isoform 6 is phosphorylated on Ser-463.
Similarity:
Belongs to the BBP/SF1 family.
Contains 1 CCHSLCtype zinc finger.
Contains 1 KH domain.
SWISS:
Q15637
Gene ID:
7536
Database links:
Entrez Gene: 7536 Human
Entrez Gene: 22668 Mouse
SwissProt: Q15637 Human
SwissProt: Q64213 Mouse
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