Rabbit Anti-phospho-Moesin (Thr558) antibody

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Moesin (phospho T558); p-Moesin (phospho T558); Membrane organizing extension spike protein; Membrane-organizing extension spike protein; MOES_HUMAN; Moesin; Moesin/anaplastic lymphoma kinase fusion protein; MSN; MSN/ALK fusion.

Cat:

SL17703R

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Cow,Sheep,)

Immunogen：

KLH conjugated synthesised phosphopeptide derived from human Moesin around the phosphorylation site of Thr558:YK(p-T)LR

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $256.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Moesin (for membrane-organizing extension spike protein) is a member of the ERM family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Moesin is localized to filopodia and other membranous protrusions that are important for cell-cell recognition and signaling and for cell movement. [provided by RefSeq, Jul 2008]

Function:
Probably involved in connections of major cytoskeletal structures to the plasma membrane.

Subcellular Location:
Cell membrane. Cytoplasm; cytoskeleton. Apical cell membrane. Cell projection; microvillus membrane. Phosphorylated form is enriched in microvilli-like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non-phosphorylated forms seen after thrombin treatment.

Tissue Specificity:
In all tissues and cultured cells studied.

Post-translational modifications:
Phosphorylation on Thr-558 is crucial for the formation of microvilli-like structures.

Similarity:
Contains 1 FERM domain.

SWISS:
P26038

Gene ID:
4478

Database links:

Entrez Gene: 4478 Human

Entrez Gene: 17698 Mouse

Omim: 309845 Human

SwissProt: P26038 Human

SwissProt: P26041 Mouse

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