Dietary fat absorption from the small intestine is facilitated by acyl-CoA:monoacylglycerol transferase (MOGAT; EC 2.3.1.22) and acyl-CoA:diacylglycerol acyltransferase (DGAT; see MIM 60980) activities. MOGAT catalyzes the joining of monoacylglycerol and fatty acyl-CoAs to form diacylglycerol (Yen and Farese, 2003 [PubMed 12621063]).[supplied by OMIM, Mar 2008]
Function:
Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.
Subcellular Location:
Endoplasmic reticulum membrane.
Tissue Specificity:
Highly expressed in liver, small intestine, colon, stomach and kidney.
Similarity:
Belongs to the diacylglycerol acyltransferase family.
SWISS:
Q3SYC2
Gene ID:
80168
Database links:
Entrez Gene: 80168 Human
Entrez Gene: 233549 Mouse
Entrez Gene: 681211 Rat
Omim: 610270 Human
SwissProt: Q3SYC2 Human
SwissProt: Q80W94 Mouse
Unigene: 288568 Human
Unigene: 208030 Mouse
Unigene: 19175 Rat
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