Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and, thus, to a cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. MCT14 (monocarboxylate transporter 14), also known as SLC16A14 (solute carrier family 16, member 14), is a 510 amino acid multi-pass membrane protein that belongs to the MCT family and functions as a proton-linked monocarboxylate transporter, effectively catalyzing the rapid transport of monocarboxylates across the membrane. Multiple isoforms of MCT14 exist due to alternative splicing events.
Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates.
Subcellular Location:
Cell membrane.
Similarity:
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
SWISS:
Q7RTX9
Gene ID:
151473
Database links:
Entrez Gene: 151473 Human
Entrez Gene: 71781 Mouse
SwissProt: Q7RTX9 Human
SwissProt: Q8K1C7 Mouse
Unigene: 504317 Human
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