MOSC2 is a 335 amino acid peripheral membrane protein that localizes to the mitochondria. Containing a MOSC domain, MOSC2 utilizes molybdenum as a cofactor and is a component of the benzamidoxime prodrug-converting complex that is comprised of cytochrome b5, NADH-cytochrome b5 reductase (CYB5R3). CYB5R3 belongs to the flavoprotein pyridine nucleotide cytochrome reductase family and is involved in the desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism and, in erythrocytes, methemoglobin reduction. Benzamidoxime prodrug-converting complex is required to reduce N-hydroxylated structures, such as benzamidoxime prodrug. MOSC2 exists as two alternatively spliced isoforms and is encoded by a gene mapping to human chromosome 1q41.
Function:
Catalytic component of the benzamidoxime prodrug-converting complex, a complex required to reduce N-hydroxylated structures, such as benzamidoxime prodrug. Benzamidoxime is an amidine prodrug produced by N-hydroxylation which is used to enhance bioavailability and increase intestinal absorption. It is then reduced into benzamidine, its active amidine, by the benzamidoxime prodrug-converting complex.
Subcellular Location:
Mitochondrion outer membrane.
Similarity:
Contains 1 MOSC domain.
SWISS:
Q969Z3
Gene ID:
54996
Database links:
Entrez Gene: 54996 Human
Entrez Gene: 67247 Mouse
SwissProt: Q969Z3 Human
SwissProt: Q922Q1 Mouse
Unigene: 369042 Human
Unigene: 177724 Mouse
|
|