MPHOSPH8 is a 860 amino acid nuclear protein that is phosphorylated in the M (mitotic) phase of the cell cycle. MPHOSPH8 contains four ANK repeats, motifs that are typically found in transcriptional regulators and cell cycle proteins and may be involved in protein-protein binding. Due to evidence suggesting that MPHOSPH8 forms a complex with Muskelin and Ran BP-M, a GTPase implicated in a diverse array of cellular processes, it may play a role in the Ran GTPase cycle. The gene encoding MPHOSPH8 resides on chromosome 13. There are two isoforms of MPHOSPH8 that are produced as a result of alternative splicing events.
Subcellular Location:
Nucleus.
Post-translational modifications:
Phosphorylated in M (mitotic) phase.
Similarity:
Contains 4 ANK repeats.
Contains 1 chromo domain.
SWISS:
Q99549
Gene ID:
54737
Database links:
Entrez Gene: 467217 Chimpanzee
Entrez Gene: 54737 Human
Entrez Gene: 75339 Mouse
Entrez Gene: 290270 Rat
Omim: 611626 Human
SwissProt: Q99549 Human
SwissProt: Q3TYA6 Mouse
SwissProt: G3V8T1 Rat
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