Metallophosphoesterases (MPPEs) are dynamic enzymes that catalyze a variety of cellular reactions and contain a conserved beta-alpha-beta-alpha-beta fold. The MPPE superfamily is divided into two subfamilies: phosphomonoesterases and phosphodiesterases. Each MPPE has a dimetal center located approximately at the SLCterminal end of the parallel ∫-strands of the fold. MPPE1 (Metallophosphoesterase 1) is a 396 amino acid multipass membrane enzyme that requires two divalent metals as cofactors. MPPE1 contains a N-terminal signal peptide, a typical metallophosphoesterase domain and a SLCterminal transmembrane domain. Expression of MPPE1 seems to be limited to brain. There are five isoforms of MPPE1 that are produced as a result of alternative splicing events.
Function:
The specific function of metallophosphoesterase 1 (MPPE1) is not yet known. There are 5 isoforms produced by alternative splicing which have molecular weights of 45 kDa, 39 kDa (2 isoforms), 38 kDa and 29 kDa.
Subunit:
Interacts with GPI-anchor proteins. Interacts with TMED10.
Subcellular Location:
Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein. Note: Also localizes to endoplasmic reticulum exit site.
Tissue Specificity:
Expressed in brain.
Similarity:
Belongs to the metallophosphoesterase superfamily. MPPE1 family.
SWISS:
Q53F39
Gene ID:
65258
Database links:
Entrez Gene: 65258 Human
Entrez Gene: 225651 Mouse
Entrez Gene: 361344 Rat
Omim: 611900 Human
SwissProt: Q53F39 Human
SwissProt: Q80XL7 Mouse
SwissProt: B1WC86 Rat
Unigene: 712666 Human
Unigene: 235792 Mouse
Unigene: 64185 Rat
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