This gene encodes an intracellular protein that interacts with members of the MORF4/MRG (mortality factor on chromosome 4/MORF4 related gene) family and the tumor suppressor Rb (retinoblastoma protein.) The protein may play a role in senescence, cell growth and immortalization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Function:
MRFAP1 is found in a complex composed of MORF4L1, MRFAP1 and RB1. It interacts via its N-terminus with MORF4L1. It also interacts with CSTB and MORF4L2.
Subcellular Location:
Nucleus. Cytoplasm; perinuclear region. Note: Colocalizes with MORF4L1 to cell nuclei.
Similarity:
Belongs to the MORF4 family-associated protein family.
SWISS:
Q9Y605
Gene ID:
93621
Database links:
Entrez Gene: 93621 Human
Entrez Gene: 545208 Mouse
SwissProt: Q9Y605 Human
SwissProt: Q9CQL7 Mouse
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