Mas-related G protein-coupled receptor member X1 (MRGX) is a sensory neuron-specific G protein-coupled receptor that is involved in the function of nociceptive neurons. This integral membrane protein may also regulate nociceptor development and/or the sensation or modulation of pain. There are four members (MRGX1-4) in the human MRGX familly. MRGX1 and MRGX2 receptors stimulate both G?q- and G?i -regulated pathways, while MRGX3 and MRGX4 receptors mainly activate G?q-regulated pathways. G?q proteins are involved in the calcium-signaling pathway downstream of the MRGX receptors. MRGX receptors are unique in that they are expressed in a subset of small dorsal root and trigeminal sensory neurons.
Function:
Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.
Similarity:
Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
SWISS:
Q96LA9
Gene ID:
117196
Database links:
Entrez Gene: 117196 Human
Omim: 607230 Human
SwissProt: Q96LA9 Human
Unigene: 632138 Human
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