MRM1 is a 353 amino acid protein that localizes to the mitochondrion and belongs to the RNA methyltransferase trmH family. Expressed as two alternatively spliced isoforms, MRM1 specifically methylates the ribose of guanosine G-2270 in the peptidyl transferase center of the mitochondrial large ribosomal RNA (21S). The gene encoding MRM1 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Function:
Probably methylates the ribose of guanosine G-2270 in the peptidyl transferase center of the mitochondrial large ribosomal RNA (21S).
Subcellular Location:
Mitochondrion.
Similarity:
Belongs to the RNA methyltransferase TrmH family.
SWISS:
Q6IN84
Gene ID:
79922
Database links:
Entrez Gene: 79922 Human
Entrez Gene: 217038 Mouse
Entrez Gene: 363661 Rat
SwissProt: Q6IN84 Human
SwissProt: Q99J25 Mouse
Unigene: 194864 Human
Unigene: 280825 Mouse
Unigene: 43486 Rat
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