Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms. [provided by RefSeq, Jul 2008]
Subcellular Location:
Mitochondrion.
Similarity:
Belongs to the ribosomal protein L4P family.
SWISS:
Q9BYD3
Gene ID:
51073
Database links:
Entrez Gene: 51073 Human
Entrez Gene: 363023 Rat
Omim: 611823 Human
SwissProt: Q9BYD3 Human
Unigene: 279652 Human
Unigene: 13113 Rat
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