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Rabbit Anti-MRPL40 antibody
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome. [provided by RefSeq, Jul 2008]
Subcellular Location:
Mitochondrion.
Tissue Specificity:
Ubiquitous.
SWISS:
Q9NQ50
Gene ID:
64976
Database links:
Entrez Gene: 64976 Human
Omim: 605089 Human
SwissProt: Q9NQ50 Human
Unigene: 431307 Human
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